Machines and equipment for asphalt pavement milling are widely used throughout the world.With the growth of road construction, the demand for this class of machinery also rises.At the Protein same time, the optimization of design and technological parameters of the milling machines is impossible without a comprehensive study of processes of milling
Cellular and functional evaluation of LDLR missense variants reported in hypercholesterolemic patients demonstrates their hypomorphic impacts on trafficking and LDL internalization
BackgroundFamilial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by increased LDL-cholesterol levels.About 85% of FH cases are caused by LDLR mutations encoding the low-density lipoprotein receptor (LDLR).LDLR is synthesized in the endoplasmic reticulum (ER) where it undergoes post-translational modifications and then tr
Addressing the need for rapid treatment of agitation in schizophrenia and bipolar disorder: focus on inhaled loxapine as an alternative to injectable agents
Leslie CitromeDepartment of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USAAbstract: Agitation (excessive motor or verbal activity) can be associated with schizophrenia or bipolar mania, and can further escalate into aggressive behavior and potentially lead to injuries in patients and staff.Medications used to treat
DAMPs from death to new life
Protein Our body handles tissue damage by activating the immune system in response to intracellularmolecules released by injured tissues (Damage-Associated Molecular Patterns, DAMPs), in a similar way as it detects molecular motifs conserved in pathogens (pathogen-associated molecular patterns, PAMPs).DAMPs are molecules that have a physiological r